Interdisciplinary Epilepsy Center, Department of Neurology, Philipps-Universität Marburg, Marburg, Germany.
Epilepsy Behav. 2010 Feb;17(2):246-51. doi: 10.1016/j.yebeh.2009.12.013. Epub 2010 Jan 25.
Memory for public events (PEs) was assessed as a marker of remote declarative memory in 36 patients with temporal lobe epilepsy (TLE) and compared with that of 19 patients with extra-TLE (ETLE), 17 patients with idiopathic generalized epilepsy (IGE), and 23 healthy volunteers. Verbal IQ, inventory-based evidence of depression, handedness, onset of illness, disease duration, and medication were obtained. Memory for PEs was reduced in all patient groups (TLE, P<0.0001; ETLE, P=0.009; IGE, P=0.008). The TLE group showed reduced memory for PEs compared with the other patients with epilepsy (P=0.001). A time gradient was observed, with worse memory for PEs of the 1990 s and for PEs that occurred after onset of illness. Our data support the key role of the temporal lobe in remote declarative memory. With patients with TLE remembering fewer PEs from the period after onset of epilepsy, the deficits can be partly attributed to unsuccessful consolidation rather than retrieval difficulties alone.
对 36 例颞叶癫痫（TLE）患者和 19 例颞叶外癫痫（ETLE）患者、17 例特发性全面性癫痫（IGE）患者及 23 名健康志愿者的公众事件记忆（PEs）进行评估，作为远程陈述性记忆的标志物。获得了言语智商、基于量表的抑郁证据、利手性、发病年龄、疾病持续时间和用药情况。所有患者组的 PEs 记忆均降低（TLE，P<0.0001；ETLE，P=0.009；IGE，P=0.008）。TLE 组的 PEs 记忆较其他癫痫患者组降低（P=0.001）。观察到时间梯度，20 世纪 90 年代和发病后发生的 PEs 记忆较差。我们的数据支持了颞叶在远程陈述性记忆中的关键作用。由于 TLE 患者对癫痫发作后时期的 PEs 记忆较少，因此这些缺陷部分归因于巩固失败，而不仅仅是检索困难。
