Kimura Michitaka, Tojo Takashi, Naito Hiroshi, Nagata Yoko, Kawai Norikazu, Taniguchi Shigeki
Department of Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Shijo-cho 840, Kashihara, Nara 634-8522, Japan.
Interact Cardiovasc Thorac Surg. 2010 Apr;10(4):568-71. doi: 10.1510/icvts.2009.225110. Epub 2010 Jan 21.
We examined the effect of a simple intraoperative intrathoracic hyperthermotherapy (IIH) and a simple intraoperative intrathoracic hyperthermo-chemotherapy (IIHC) on malignant pleural effusion and/or dissemination with primary non-small lung cancer. This study included 19 patients who had malignant pleural effusion and/or dissemination recognized for the first time at the time of surgery. We performed surgical procedures on the primary lesions and then the additional therapies followed. Seven patients received IIH (group A), five patients underwent IIHC (group B), and seven patients did not have any additional therapy (group C). There was no death during the follow-up period (9-35 months) in the group A. The median survival time was 41 months in the group B and 25 months in the group C. The group A was completely free of pleural effusion and one patient in the group B suffered from pleural effusion 26 months after surgery, although the median term of freedom from pleural effusion was three months in the group C. In patients with malignant pleural effusion and/or dissemination with primary non-small lung cancer, not only IIHC but also IIH might be beneficial in the prevention of pleural effusion instead of the improvement in prognosis.
我们研究了单纯术中胸腔内热疗（IIH）和单纯术中胸腔内热化疗（IIHC）对原发性非小细胞肺癌所致恶性胸腔积液和/或播散的影响。本研究纳入了19例在手术时首次发现有恶性胸腔积液和/或播散的患者。我们先对原发灶进行手术操作，然后进行额外治疗。7例患者接受IIH（A组），5例患者接受IIHC（B组），7例患者未接受任何额外治疗（C组）。A组在随访期（9 - 35个月）内无死亡病例。B组的中位生存时间为41个月，C组为25个月。A组完全没有胸腔积液，B组有1例患者在术后26个月出现胸腔积液，而C组胸腔积液无复发的中位时间为3个月。对于原发性非小细胞肺癌伴有恶性胸腔积液和/或播散的患者，不仅IIHC，而且IIH在预防胸腔积液方面可能有益，而非改善预后。
