Department of Allergy, Kanagawa Children's Medical Center, Kanagawa, Japan.
Allergol Int. 2010 Mar;59(1):9-14. doi: 10.2332/allergolint.09-RAI-0152. Epub 2010 Feb 25.
Although the current standard care for patients with food allergy is based on avoidance of the trigger foods with hope of possible gain of tolerance, increasing number of studies have shown that oral immunotherapy is a promising approach. Understanding the transcutaneous sensitization and oral immune tolerance to food antigens has shifted focus of treatment and prevention. However, more studies are warranted to elucidate the underlying mechanisms and to clarify the indication criteria to which type of patients this therapy should be applied. Easy and uncontrolled use of elimination diets for atopic dermatitis might have increased and exacerbated food allergy, and thorough innovation of our whole concept for food allergy is now required.
尽管目前食物过敏患者的标准治疗方法是避免食用致敏食物,以期获得可能的耐受,但越来越多的研究表明,口服免疫疗法是一种很有前途的方法。对食物抗原经皮致敏和口服免疫耐受的理解改变了治疗和预防的重点。然而,需要更多的研究来阐明潜在的机制,并阐明应该将这种治疗应用于哪种类型患者的适应证标准。特应性皮炎的消除饮食的简单和不受控制的使用可能会增加和加重食物过敏,现在需要对我们的整个食物过敏概念进行彻底的创新。