Divisions of Public Health Sciences and Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 98109 Seattle, USA.
Nat Rev Cancer. 2010 Feb;10(2):87-101. doi: 10.1038/nrc2773.
The public health importance of Barrett's oesophagus lies in its association with oesophageal adenocarcinoma. The incidence of oesophageal adenocarcinoma has risen at an alarming rate over the past four decades in many regions of the Western world, and there are indications that the incidence of this disease is on the rise in Asian populations in which it has been rare. Much has been learned of host and environmental risk factors that affect the incidence of oesophageal adenocarcinoma, and data indicate that patients with Barrett's oesophagus rarely develop oesophageal adenocarcinoma. Given that 95% of oesophageal adenocarcinomas arise in individuals without a prior diagnosis of Barrett's oesophagus, what strategies can be used to reduce late diagnosis of oesophageal adenocarcinoma?
巴雷特食管的公共卫生重要性在于其与食管腺癌的关联。在过去的四十年中，在西方世界的许多地区，食管腺癌的发病率以惊人的速度上升，有迹象表明，在亚洲人群中，这种疾病的发病率在罕见的情况下也在上升。人们已经了解了许多宿主和环境危险因素，这些因素会影响食管腺癌的发病率，并且数据表明，患有巴雷特食管的患者很少发展为食管腺癌。鉴于 95%的食管腺癌发生在没有巴雷特食管先前诊断的个体中，那么有哪些策略可以用于减少食管腺癌的晚期诊断？
