巴雷特食管的化学预防
Chemoprevention in Barrett's oesophagus.
作者信息
Baruah Anushka, Buttar Navtej S
机构信息
Mayo Clinic College of Medicine, Department of Gastroenterology and Hepatology, Rochester, MN, USA.
Mayo Clinic College of Medicine, Department of Gastroenterology and Hepatology, Rochester, MN, USA.
出版信息
Best Pract Res Clin Gastroenterol. 2015 Feb;29(1):151-65. doi: 10.1016/j.bpg.2014.12.003. Epub 2014 Dec 29.
Increasing incidence of oesophageal adenocarcinoma along with poor survival entails novel preventive strategies. Agents that target pro-oncogenic pathways in Barrett's mucosa could halt this neoplastic transformation. In this review, we will use epidemiological associations and molecular mechanisms to identify novel chemoprevention targets in Barrett's oesophagus. We will also discuss recent chemoprevention trials.
食管腺癌发病率不断上升且生存率低，这需要新的预防策略。针对巴雷特食管化生黏膜中促癌途径的药物可能会阻止这种肿瘤转化。在这篇综述中，我们将利用流行病学关联和分子机制来确定巴雷特食管中新的化学预防靶点。我们还将讨论最近的化学预防试验。
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