State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, 100029, Beijing, People's Republic of China.
Amino Acids. 2010 Jul;39(2):533-8. doi: 10.1007/s00726-009-0469-7. Epub 2010 Jan 22.
A series of phosphinopeptides containing C-terminal alpha-aminoalkylphosphinic acids were prepared in good yields directly in one-pot reactions of 2-(N-benzoxycarbonylamino)alkanamides/peptide amides, aldehydes, and aryldichlorophosphines, followed by hydrolysis. In the current method, the peptide bond was formed in a Mannich-type reaction.
一系列含有 C 末端α-氨基烷基亚膦酸的磷肽可直接通过 2-（N-苯甲氧基羰基氨基）烷酰胺/肽酰胺、醛和芳基二氯膦的一锅反应高产率制备，然后进行水解。在当前方法中，肽键是通过曼尼希型反应形成的。
