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孕妇尿液中的碘、硒和其他微量元素。

Iodine, selenium, and other trace elements in urine of pregnant women.

机构信息

Department of Endocrinology, Medical College, Jagiellonian University, Kraków, Poland.

出版信息

Biol Trace Elem Res. 2010 Dec;138(1-3):28-41. doi: 10.1007/s12011-009-8601-9. Epub 2010 Jan 22.

Abstract

The purpose of this work was to determine trace element levels in urine and evaluate possible associations between urinary iodine concentration (UIC), other trace elements (Cr, Cu, Fe, Mn, Na, Se, Zn), toxic elements (Cd, Pb), anthropometrical measures (body weight and height), glycemic indices (serum insulin and glucose), and several parameters related to thyroid function (thyroid stimulating hormone, free thyroxine, antithyroid peroxidase antibodies, thyroid volume, and thyroid echogenicity) in pregnant women. One hundred sixty-nine participants were recruited. The whole study group, originating from Krakow region, comprised three subgroups belonging to three trimesters: I trimester (n = 28), II trimester (n = 83), and III trimester (n = 58). Trace elements were determined using inductively coupled plasma mass/(atomic emission) spectrometry. Partial least square model was used to reveal correlation structure between parameters investigated, as well as a possible causal relationship between dependent parameters and potentially explanatory parameters. Results obtained for trace and toxic elements in urine were comparable with results of other authors, although the study group was not homogenous. We confirmed (1) low iodine excretion in pregnant women, (2) the existence of statistically significant correlation between UIC and urinary selenium, and (3) lack of correlation between latter parameter and typical indices of thyroid function. Urinary selenium correlated with other urinary trace elements, but physiological significance of this finding remains uncertain. The fact that a large number of pregnant women fail to meet dietary recommendations for iodine is the major reason for concern.

摘要

本研究旨在测定尿液中的微量元素水平,并评估尿碘浓度(UIC)与其他微量元素(Cr、Cu、Fe、Mn、Na、Se、Zn)、有毒元素(Cd、Pb)、人体测量指标(体重和身高)、血糖指数(血清胰岛素和葡萄糖)以及与甲状腺功能相关的几个参数(促甲状腺激素、游离甲状腺素、抗甲状腺过氧化物酶抗体、甲状腺体积和甲状腺回声)之间的可能相关性。研究共招募了 169 名参与者。整个研究组来自克拉科夫地区,分为三个三个月龄组:I 期(n = 28)、II 期(n = 83)和 III 期(n = 58)。使用电感耦合等离子体质谱/原子发射光谱法测定微量元素。采用偏最小二乘模型揭示了研究参数之间的相关结构,以及依赖参数与潜在解释参数之间的可能因果关系。尿液中痕量和有毒元素的结果与其他作者的结果相当,但研究组并不均匀。我们证实了(1)孕妇碘排泄量低,(2)UIC 与尿硒之间存在统计学显著相关性,(3)后一参数与典型甲状腺功能指标之间缺乏相关性。尿硒与其他尿微量元素相关,但这一发现的生理意义尚不确定。大量孕妇未能满足碘的膳食推荐量是主要关注的原因。

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