Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario M4N 3M5, Canada.
Med Phys. 2009 Dec;36(12):5437-43. doi: 10.1118/1.3250863.
For dosimetry and for work in optimization of x-ray imaging of the breast, it is commonly assumed that the breast is composed of 50% fibroglandular tissue and 50% fat. The purpose of this study was to assess whether this assumption was realistic.
First, data obtained from an experimental breast CT scanner were used to validate an algorithm that measures breast density from digitized film mammograms. Density results obtained from a total of 2831 women, including 191 women receiving CT and from mammograms of 2640 women from three other groups, were then used to estimate breast compositions.
Mean compositions, expressed as percent fibroglandular tissue (including the skin), varied from 13.7% to 25.6% among the groups with an overall mean of 19.3%. The mean compressed breast thickness for the mammograms was 5.9 cm (sigma = 1.6 cm). 80% of the women in our study had volumetric breast density less than 27% and 95% were below 45%.
Based on the results obtained from the four groups of women in our study, the "50-50" breast is not a representative model of the breast composition.
为了进行放射剂量学研究以及优化乳房 X 射线成像,通常假设乳房由 50%的纤维腺体组织和 50%的脂肪组成。本研究旨在评估这种假设是否合理。
首先,使用来自实验性乳房 CT 扫描仪的数据验证了一种从数字化胶片乳房 X 光片中测量乳房密度的算法。然后,使用总共 2831 名女性的数据,包括 191 名接受 CT 检查的女性和来自另外三组的 2640 名女性的乳房 X 光片数据,来估计乳房成分。
各组的平均纤维腺体组织(包括皮肤)含量以百分比表示,范围为 13.7%至 25.6%,总体平均值为 19.3%。乳房 X 光片的平均压缩厚度为 5.9 厘米(标准差为 1.6 厘米)。在我们的研究中,80%的女性的体积乳房密度小于 27%,95%的女性的体积乳房密度小于 45%。
根据我们研究的四组女性的结果,“50-50”乳房并不是乳房成分的代表性模型。