Gan'shina T S, Kurdiumov I N, Turilova A I, Mirzoian R S, Seredenin S B
Eksp Klin Farmakol. 2009 Nov-Dec;72(6):18-21.
Narcotized rats under hemorrhagic stroke model conditions exhibit a significant decrease in the cerebral flow in the region of contralateral cerebral hemisphere symmetric to the zone of lesion. Under these conditions, afobazole produced a significant increase in the local circulation in cerebral cortex, which was violated by hemorrhagic stroke. The cerebrovascular effect of afobazole was not manifested in cases of hemorrhagic stroke on the background of GABA receptor blocking by bicuculline. The obtained results demonstrate that afobazole increases the cerebral blood flow not only under conditions of global transient cerebral ischemia, but on the hemorrhagic stroke model as well, which is probably related to a mediated drug effect on the GABA receptor complex.
在出血性中风模型条件下，麻醉大鼠对侧大脑半球与损伤区域对称的区域脑血流量显著减少。在这些条件下，阿福唑产生了出血性中风所破坏的大脑皮质局部循环的显著增加。在荷包牡丹碱阻断GABA受体的情况下，出血性中风时阿福唑的脑血管效应未表现出来。所得结果表明，阿福唑不仅在全脑短暂性脑缺血条件下增加脑血流量，而且在出血性中风模型上也有此作用，这可能与药物对GABA受体复合物的介导作用有关。
