[Neuroprotective effects of afobazole in a hemorrhagic stroke model].

The model of posttraumatic hematoma was used to imitate the condition of hemorrhagic stroke in rats. Afobazole (5-ethoxy-2-[2-(morpholino)-ethylthio] benzimidazole dihydrochloride) administered in doses of 0.1 and 1.0 mg/kg intraperitoneally for 14 days was shown to be able to decrease the pathological manifestations of this model. Afobazole administration decreased mortality and the neurological deficits, including motor discoordination, and improve the learning and memory.