Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
Langmuir. 2010 Apr 6;26(7):5115-21. doi: 10.1021/la903592s.
The feasibility of producing a hollow microsphere with a single hole in its shell by coaxial electrohydrodynamic atomization (CEHDA) is demonstrated. Polymethylsilsesquioxane (PMSQ) was used as a model shell material encapsulating a core of a volatile liquid, perfluorohexane (PFH), which was subsequently evaporated to produce the hollow microspheres. The diameters of the microspheres and of the single surface pore were controlled by varying the flow rate of the components, the concentration of the PMSQ solution, and the applied voltage in the CEHDA process. The particles were characterized by scanning electron microscopy, and the ranges obtained were 275-860 nm for the microsphere diameter and 35-135 nm for the pore size. The process overcomes several of the key problems associated with existing methods of monoporous microsphere formation including removing the need for elevated temperatures, multiple processing steps, and the use of surfactants and other additives.
同轴电喷射雾化（CEHDA）法制备壳层带单孔的中空微球的可行性得到了验证。采用聚甲基倍半硅氧烷（PMSQ）作为壳层材料，包覆挥发性液体全氟己烷（PFH）芯材，随后蒸发掉芯材以制备中空微球。通过改变 CEHDA 过程中各组分的流速、PMSQ 溶液的浓度和外加电压来控制微球和单孔表面孔径的直径。通过扫描电子显微镜对颗粒进行了表征，获得的粒径范围为微球直径 275-860nm，孔径 35-135nm。该工艺克服了现有单孔微球形成方法的几个关键问题，包括无需高温、多个处理步骤以及表面活性剂和其他添加剂的使用。
