同轴电喷射法用于生物医学应用的微纳米粒子制备。
Coaxial electrospray of microparticles and nanoparticles for biomedical applications.
机构信息
Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
出版信息
Expert Rev Med Devices. 2012 Nov;9(6):595-612. doi: 10.1586/erd.12.58.
Abstract
Coaxial electrospray is an electrohydrodynamic process that produces multilayer microparticles and nanoparticles by introducing coaxial electrified jets. In comparison with other microencapsulation/nanoencapsulation processes, coaxial electrospray has several potential advantages such as high encapsulation efficiency, effective protection of bioactivity and uniform size distribution. However, process control in coaxial electrospray is challenged by the multiphysical nature of the process and the complex interplay of multiple design, process and material parameters. This paper reviews the previous works and the recent advances in design, modeling and control of a coaxial electrospray process. The review intends to provide general guidance for coaxial electrospray and stimulate further research and development interests in this promising microencapsulation/nanoencapsulation process.
摘要
同轴静电喷雾是一种通过引入同轴带电射流来生产多层微颗粒和纳米颗粒的电流体动力学过程。与其他微胶囊化/纳米胶囊化工艺相比，同轴静电喷雾具有几个潜在的优势，如高封装效率、有效保护生物活性和均匀的粒径分布。然而，同轴静电喷雾的过程控制受到多物理性质和多个设计、过程和材料参数复杂相互作用的挑战。本文综述了同轴静电喷雾设计、建模和控制方面的前期工作和最新进展。综述旨在为同轴静电喷雾提供一般性指导，并激发人们对这一有前途的微胶囊化/纳米胶囊化工艺的进一步研究和开发兴趣。
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ACS Nano. 2012 Mar 27;6(3):2245-52. doi: 10.1021/nn204300s. Epub 2012 Feb 22.
2
Theranostic applications of nanomaterials in cancer: drug delivery, image-guided therapy, and multifunctional platforms.纳米材料在癌症中的治疗诊断应用：药物输送、影像引导治疗和多功能平台。
Appl Biochem Biotechnol. 2011 Dec;165(7-8):1628-51. doi: 10.1007/s12010-011-9383-z. Epub 2011 Sep 27.
3
A multiplexed electrospray process for single-step synthesis of stabilized polymer particles for drug delivery.用于药物传递的稳定聚合物颗粒的单步合成的多重化电喷雾工艺。
J Control Release. 2011 Sep 5;154(2):203-10. doi: 10.1016/j.jconrel.2011.05.018. Epub 2011 May 26.
4
Coaxial electrospray formulations for improving oral absorption of a poorly water-soluble drug.同轴电喷雾制剂改善难溶性药物口服吸收的研究
Mol Pharm. 2011 Jun 6;8(3):807-13. doi: 10.1021/mp100401d. Epub 2011 Mar 25.
5
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J Biomed Opt. 2011 Feb;16(2):020507. doi: 10.1117/1.3548878.
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Langmuir. 2011 Feb 1;27(3):1175-80. doi: 10.1021/la1042734. Epub 2010 Dec 23.
7
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Int J Pharm. 2011 Feb 14;404(1-2):110-5. doi: 10.1016/j.ijpharm.2010.11.014. Epub 2010 Nov 17.
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J Biomed Opt. 2010 Jul-Aug;15(4):046010. doi: 10.1117/1.3469829.
9
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Biomaterials. 2010 Nov;31(33):8732-40. doi: 10.1016/j.biomaterials.2010.07.080. Epub 2010 Aug 14.
10
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