Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.
Expert Rev Med Devices. 2012 Nov;9(6):595-612. doi: 10.1586/erd.12.58.
Coaxial electrospray is an electrohydrodynamic process that produces multilayer microparticles and nanoparticles by introducing coaxial electrified jets. In comparison with other microencapsulation/nanoencapsulation processes, coaxial electrospray has several potential advantages such as high encapsulation efficiency, effective protection of bioactivity and uniform size distribution. However, process control in coaxial electrospray is challenged by the multiphysical nature of the process and the complex interplay of multiple design, process and material parameters. This paper reviews the previous works and the recent advances in design, modeling and control of a coaxial electrospray process. The review intends to provide general guidance for coaxial electrospray and stimulate further research and development interests in this promising microencapsulation/nanoencapsulation process.
同轴静电喷雾是一种通过引入同轴带电射流来生产多层微颗粒和纳米颗粒的电流体动力学过程。与其他微胶囊化/纳米胶囊化工艺相比，同轴静电喷雾具有几个潜在的优势，如高封装效率、有效保护生物活性和均匀的粒径分布。然而，同轴静电喷雾的过程控制受到多物理性质和多个设计、过程和材料参数复杂相互作用的挑战。本文综述了同轴静电喷雾设计、建模和控制方面的前期工作和最新进展。综述旨在为同轴静电喷雾提供一般性指导，并激发人们对这一有前途的微胶囊化/纳米胶囊化工艺的进一步研究和开发兴趣。
