Tsou Tsung-Pei, Lin Chien-Hui, Lo Yi-Chun, Li Yi-Syue, Chiu Chan-Hsien
Epidemic Intelligence Center, Taiwan Centers for Disease Control, Taipei, Taiwan.
Scand J Infect Dis. 2010 May;42(5):375-8. doi: 10.3109/00365540903499423.
Influenza is a frequent cause of acute respiratory illness (ARI). In July 2008, we conducted a retrospective cohort study to investigate an influenza outbreak occurring in an overland travel group of overseas students. ARI was defined as the presence of any respiratory symptom such as cough, rhinorrhoea, sore throat or stuffy nose. Influenza-like illness (ILI) was defined as ARI plus fever > or =38 degrees C. Throat swabs were taken from symptomatic participants and a real-time polymerase chain reaction (RT-PCR) was performed. One hundred and seventy participants were interviewed. Forty-four (26%) had an ARI and 22 (13%) had an ILI. Of the 33 specimens collected, 18 (54%) were positive for influenza A/H3N2. Taiwanese group leaders had increased risk of acquiring both ARI and ILI (ARI relative risk (RR) 2.2, 95% confidence interval (CI) 1.3-3.7 and ILI RR 2.8, 95% CI 1.2-6.3). Fifteen participants were vaccinated. The vaccine effectiveness was 52% for ILI (p = 0.70). The outbreak stopped after cohorting and the use of surgical masks. Vaccination appeared to be effective in preventing infection.
流感是急性呼吸道疾病（ARI）的常见病因。2008年7月，我们开展了一项回顾性队列研究，以调查一个海外留学生陆路旅行团中发生的流感暴发。ARI定义为存在任何呼吸道症状，如咳嗽、流涕、咽痛或鼻塞。流感样疾病（ILI）定义为ARI加发热≥38摄氏度。对有症状的参与者采集咽拭子，并进行实时聚合酶链反应（RT-PCR）检测。对170名参与者进行了访谈。44人（26%）患有ARI，22人（13%）患有ILI。在采集的33份标本中，18份（54%）甲型H3N2流感呈阳性。台湾籍领队患ARI和ILI的风险增加（ARI相对风险（RR）2.2，95%置信区间（CI）1.3 - 3.7；ILI RR 2.8，95% CI 1.2 - 6.3）。15名参与者接种了疫苗。疫苗对ILI的有效性为52%（p = 0.70）。在进行队列隔离和使用外科口罩后，疫情得到控制。接种疫苗似乎对预防感染有效。
