比较青蒿幼叶和成熟叶精油及其主要成分的体外自由基清除活性。
In vitro screening of essential oil from young and mature leaves of Artemisia scoparia compared to its major constituents for free radical scavenging activity.
机构信息
Department of Environment and Vocational Studies, Panjab University, Chandigarh 160 014, India.
出版信息
Food Chem Toxicol. 2010 Apr;48(4):1040-4. doi: 10.1016/j.fct.2010.01.017. Epub 2010 Jan 21.
The present study investigated the chemical characterization, and antioxidant activity of essential oil hydrodistilled from young and mature leaves of Artemisia scoparia. GC-MS analyses revealed a monoterpenoid nature (64-67%) with 44 and 31 constituents in young and mature leaves oil, respectively. The oil from young leaf contained greater amount of oxygenated compounds. Beta-myrcene (24.13%) and p-cymene (27.06%) were the major constituents in young and mature leaves oil, respectively. A. scoparia leaf oils (25-200 microg/ml) exhibited a strong 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity and antioxidant activity against hydroxyl radical and hydrogen peroxide. However, the activities of major constituent monoterpenes, beta-myrcene and p-cymene, were less. In general, the DPPH radical scavenging and antioxidant activity was in the order: mature leaf oil > young leaf oil > beta-myrcene > p-cymene.
本研究调查了从青蒿幼叶和成熟叶中提取的精油的化学特征和抗氧化活性。GC-MS 分析表明，该精油具有单萜烯性质（64-67%），幼叶和成熟叶油分别含有 44 和 31 种成分。幼叶油含有更多的含氧化合物。β-月桂烯（24.13%）和对伞花烃（27.06%）分别是幼叶和成熟叶油的主要成分。青蒿叶油（25-200μg/ml）对 2,2-二苯基-1-苦基肼自由基具有很强的清除能力，对羟基自由基和过氧化氢也具有抗氧化活性。然而，主要成分单萜烯β-月桂烯和对伞花烃的活性较低。总的来说，DPPH 自由基清除和抗氧化活性的顺序为：成熟叶油＞幼叶油＞β-月桂烯＞对伞花烃。
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