Neurological Sciences Institute, Oregon Health & Science University, Beaverton, OR 97006, USA.
Neuroscience. 2010 Mar 31;166(3):935-41. doi: 10.1016/j.neuroscience.2010.01.027. Epub 2010 Jan 20.
Extracellular and whole-cell light-evoked responses of mouse retinal ganglion cells were recorded in the presence of the mGluR8 selective agonist, (S)-3,4-dicarboxy-phenylglycine (DCPG). Off-light responses were reversibly reduced in the presence of DCPG in wild-type but not in mGluR8-deficient retinas. On-responses were only marginally modulated by DCPG. During Off-responses, DCPG suppressed both excitatory and inhibitory synaptic conductances suggesting that mGluR8 receptor activity reduces glutamate release from bipolar cell terminals and possibly also the release of an inhibitory neurotransmitter from amacrine cell processes.
在存在 mGluR8 选择性激动剂 (S)-3,4-二羧基苯甘氨酸 (DCPG) 的情况下，记录了小鼠视网膜神经节细胞的细胞外和全细胞光诱发反应。在野生型视网膜中，DCPG 可逆地减少了 Off-light 反应，但在 mGluR8 缺失型视网膜中则没有。On-responses 仅被 DCPG 轻微调节。在 Off-responses 期间，DCPG 抑制了兴奋性和抑制性突触电流，表明 mGluR8 受体活性减少了从双极细胞末端释放的谷氨酸和可能也减少了从无长突细胞过程中释放的抑制性神经递质。
