Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, NY 14642, USA.
Cell Signal. 2010 Jul;22(7):977-83. doi: 10.1016/j.cellsig.2010.01.010. Epub 2010 Jan 21.
Tumor necrosis factor-alpha (TNF-alpha) is a potent pro-inflammatory molecule, which upon engagement with its cognate receptors on target cells, triggers downstream signaling cascades that control a number of cellular processes related to cell viability, gene expression, ion homeostasis, and synaptic integrity. In the central nervous system (CNS), TNF-alpha is produced by brain-resident astrocytes, microglia, and neurons in response to numerous intrinsic and extrinsic stimuli. This review will summarize the key events that lead to TNF-alpha elaboration in the CNS, and the effects that these inflammatory signals impart on neuronal signaling in the context of homeostasis and neuropathology.
肿瘤坏死因子-α(TNF-α)是一种强效的促炎分子,与靶细胞上的同源受体结合后,触发下游信号级联反应,控制与细胞活力、基因表达、离子稳态和突触完整性相关的许多细胞过程。在中枢神经系统(CNS)中,TNF-α由脑驻留的星形胶质细胞、小胶质细胞和神经元在多种内在和外在刺激下产生。本综述将总结导致 CNS 中 TNF-α产生的关键事件,以及这些炎症信号在稳态和神经病理学背景下对神经元信号传递的影响。