Kamar Nassim, Abravanel Florence, Mansuy Jean-Michel, Peron Jean-Marie, Izopet Jacques, Rostaing Lionel
Service de néphrologie, dialyse et transplantation multi-organes, CHU Rangueil, TSA 50032, 31059 Toulouse cedex 9, France.
Nephrol Ther. 2010 Apr;6(2):83-7. doi: 10.1016/j.nephro.2009.10.005. Epub 2010 Jan 21.
Hepatitis E virus (HEV) causes epidemics of acute hepatitis in developing countries, and also appears to be an emerging agent in industrialized countries. HEV infection is transmitted via the fecal-oral route, and may be a zoonosis in industrialized countries. HEV infection was thought to be responsible for acute hepatitis that does not become chronic. However, it has been recently reported that HEV infection can evolve to chronic hepatitis and to cirrhosis, at least in solid-organ transplant patients. The reduction of immunosuppressive drugs could be considered as a first-line therapeutic option.
戊型肝炎病毒(HEV)在发展中国家引发急性肝炎流行,在工业化国家似乎也是一种新发致病原。HEV感染通过粪口途径传播,在工业化国家可能为人畜共患病。HEV感染曾被认为是导致不会发展为慢性的急性肝炎的病因。然而,最近有报道称,至少在实体器官移植患者中,HEV感染可进展为慢性肝炎和肝硬化。减少免疫抑制药物的使用可被视为一线治疗选择。