戊型肝炎病毒感染的流行病学和临床特征：在福贾地区（意大利南部普利亚大区）的一项调查。
Epidemiological and clinical features of HEV infection: a survey in the district of Foggia (Apulia, Southern Italy).
机构信息
Clinic of Infectious Diseases, University of Foggia, Foggia, Italy.
Institute of Hygiene, University of Foggia, Foggia, Italy.
出版信息
Epidemiol Infect. 2014 Feb;142(2):287-94. doi: 10.1017/S0950268813001167. Epub 2013 May 15.
In this study we assessed the seroprevalence of hepatitis E virus (HEV) infection in both the Italian population and immigrants from developing countries in Foggia (Apulia, Southern Italy). The seroprevalence of HEV was determined in 1217 subjects [412 (34%) immigrants and 805 Italian subjects (blood donors, general population, HIV-positive, haemodialysis patients)]. Serum samples were tested for anti-HEV and confirmed by Western blot assay; in positive patients HEV RNA and genotype were also determined. There were 8·8% of patients that were positive to anti-HEV, confirmed by Western blot. The prevalence in immigrants was 19·7%, and in Italians 3·9% (blood donors 1·3%, general population 2·7%, HIV-positive patients 2·0%, haemodialysis patients 9·6%). Anti-HEV IgM was found in 38/107 (35·5%) of the anti-HEV-positive serum samples (34 immigrants, four Italians). This study indicates a higher circulation of HEV in immigrants and Italian haemodialysis patients, whereas a low prevalence of HEV antibodies was seen in the remaining Italian population.
在这项研究中，我们评估了在福贾（意大利南部普利亚地区）的意大利人群和来自发展中国家的移民中戊型肝炎病毒（HEV）感染的血清流行率。我们在 1217 名受试者中确定了 HEV 的血清流行率[412 名（34%）移民和 805 名意大利受试者（献血者、普通人群、HIV 阳性、血液透析患者）]。血清样本经抗-HEV 检测，并通过 Western blot 检测确认；在阳性患者中还确定了 HEV RNA 和基因型。有 8.8%的患者抗-HEV 阳性，Western blot 确认。移民中的患病率为 19.7%，意大利人中为 3.9%（献血者 1.3%，普通人群 2.7%，HIV 阳性患者 2.0%，血液透析患者 9.6%）。在 107 份抗-HEV 阳性血清样本中发现了 38 份抗-HEV IgM（34 名移民，4 名意大利人）。这项研究表明，HEV 在移民和意大利血液透析患者中传播更为广泛，而在其余的意大利人群中，HEV 抗体的流行率较低。
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