Institute of Modern Biopharmaceuticals, School of Life Sciences, Southwest University, Chongqing 400715, China.
Microb Pathog. 2010 Mar-Apr;48(3-4):97-102. doi: 10.1016/j.micpath.2010.01.004. Epub 2010 Jan 22.
NrdH is one of the intracellular redoxins exist in Mycobacterium and other microorganisms lacking the common glutathione system. NrdH seems a chimeric protein of glutaredoxin amino acid sequence and thioredoxin activity. It serves as a hydrogen donor for ribonucleotide reductase. Mycobacterium tuberculosis might take advantage of this enzyme to persist in the highly oxidized host mononuclear phagocytes and maintain the balance of intracellular redox potential. Physiological role of NrdH and comparison of its genomic context organization were summarized here. The most intriguing feature might be its new drug targets potential.
NrdH 是一种存在于分枝杆菌和其他缺乏常见谷胱甘肽系统的微生物中的细胞内氧化还原酶。NrdH 似乎是谷胱甘肽还原酶氨基酸序列和硫氧还蛋白活性的嵌合蛋白。它是核糖核苷酸还原酶的氢供体。结核分枝杆菌可能利用这种酶在高度氧化的宿主单核吞噬细胞中存活下来，并维持细胞内氧化还原电势的平衡。本文总结了 NrdH 的生理作用及其基因组环境组织的比较。最有趣的特点可能是其作为新药靶点的潜力。
