Department of Gynecology, Shanghai Obstetrics/Gynecology Hospital, Shanghai, China.
Am J Obstet Gynecol. 2010 Apr;202(4):346.e1-8. doi: 10.1016/j.ajog.2009.11.035. Epub 2010 Jan 22.
We sought to investigate the expression and localization of oxytocin receptor (OTR) and transient receptor potential vanilloid type 1 (TRPV1) in women with and without adenomyosis.
Ectopic and homologous eutopic endometrium from 50 women with adenomyosis and endometrium from 18 women without adenomyosis were used for immunohistochemical analysis of OTR and TRPV1. Microscopic evaluation assessed the presence and localization of OTR and TRPV1 throughout the menstrual cycle in both eutopic endometrial and endometriotic tissues of women with adenomyosis and compared them with normal endometrium.
Compared with normal endometrium, immunoreactivity of OTR and TRPV1 were significantly increased in ectopic endometrium. Both OTR and TRPV1 immunoreactivity were positively correlated with the severity of dysmenorrhea and found to be significant predicators for dysmenorrhea severity.
These findings suggest that OTR and TRPV1 may be involved in dysmenorrhea and its severity in adenomyosis and may be potential therapeutic targets.
我们旨在研究催产素受体（OTR）和瞬时受体电位香草酸型 1（TRPV1）在患有和不患有子宫腺肌病的女性中的表达和定位。
使用 50 名患有子宫腺肌病的女性的异位和同源在位子宫内膜以及 18 名没有子宫腺肌病的女性的子宫内膜进行 OTR 和 TRPV1 的免疫组织化学分析。显微镜评估评估了在患有子宫腺肌病的女性的在位子宫内膜和子宫内膜异位组织中整个月经周期中 OTR 和 TRPV1 的存在和定位，并将其与正常子宫内膜进行了比较。
与正常子宫内膜相比，异位子宫内膜中的 OTR 和 TRPV1 免疫反应性显着增加。OTR 和 TRPV1 免疫反应性均与痛经的严重程度呈正相关，并且被发现是痛经严重程度的重要预测因子。
这些发现表明，OTR 和 TRPV1 可能参与子宫腺肌病的痛经及其严重程度，并且可能是潜在的治疗靶点。
