Clinic for Reproductive Endocrinology, Department of Gynecology and Obstetrics, University Hospital, CH-8091 Zürich, Switzerland.
Metabolism. 2011 Feb;60(2):180-5. doi: 10.1016/j.metabol.2009.12.010. Epub 2010 Jan 22.
At present, the association between adiponectin and sex hormones in women is controversial. Recent studies suggest that it is high-molecular weight (HMW) adiponectin and the HMW to total adiponectin ratio rather than total adiponectin that are associated with antiatherogenic activities, insulin sensitivity, metabolic syndrome, and prediction of cardiovascular events. The present study aimed to investigate whether measuring HMW adiponectin and the HMW to total adiponectin ratio rather than total adiponectin might be more useful to detect an association between circulating female sex steroids and adipocytokines. In a clinical trial, we investigated the associations of total adiponectin, HMW adiponectin, and the HMW to adiponectin ratio with several androgens and estradiol in 36 healthy premenopausal women with regular cycles. No association between the investigated sex hormones and adiponectin was observed. The HMW adiponectin was negatively correlated with estradiol after adjustment for age and body mass index. The HMW to total adiponectin ratio was significantly negatively associated with testosterone, free testosterone, and androstenedione. The testosterone to estradiol ratio, as a parameter for the estrogen-androgen balance, was not associated with adiponectin or the HMW isoform. In conclusion, there is a negative association between estradiol and HMW adiponectin, and between testosterone, free testosterone, and androstenedione and the HMW to adiponectin ratio. Thus, one mechanism whereby female sex steroids may influence the cardiovascular risk of women could be alteration of the relationship between HMW and total adiponectin concentrations in plasma.
目前，脂联素与女性性激素之间的关系存在争议。最近的研究表明，与其说是总脂联素，不如说是高分子量（HMW）脂联素和 HMW 与总脂联素的比值与抗动脉粥样硬化活性、胰岛素敏感性、代谢综合征以及心血管事件的预测有关。本研究旨在探讨测量 HMW 脂联素和 HMW 与总脂联素的比值而不是总脂联素是否更有助于检测循环女性性激素和脂肪细胞因子之间的关联。在一项临床试验中，我们调查了 36 名具有正常周期的健康绝经前妇女的总脂联素、HMW 脂联素和 HMW 与总脂联素的比值与几种雄激素和雌二醇之间的关系。未观察到所研究的性激素与脂联素之间存在任何关联。HMW 脂联素与雌二醇呈负相关，经年龄和体重指数调整后仍如此。HMW 与总脂联素的比值与睾酮、游离睾酮和雄烯二酮呈显著负相关。睾酮与雌二醇比值作为雌激素-雄激素平衡的一个参数，与脂联素或 HMW 同工型无关。总之，雌二醇与 HMW 脂联素之间以及睾酮、游离睾酮和雄烯二酮与 HMW 与总脂联素的比值之间存在负相关。因此，女性性激素可能影响女性心血管风险的一种机制可能是改变血浆中 HMW 和总脂联素浓度之间的关系。
