Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy.
Bioorg Med Chem. 2010 Feb 15;18(4):1702-10. doi: 10.1016/j.bmc.2009.12.059. Epub 2010 Jan 4.
A series of novel benzimidazolones and their analogues, characterized by the presence of one or more methyl groups or other bioisosteric moieties at different positions of the phenyl ring at N-1, were synthesized and evaluated as inhibitors of human immunodeficiency virus type-1 (HIV-1). Most of the new compounds proved to be highly effective in inhibiting both HIV-1 replication in MT4 cells with minimal cytotoxicity and RT enzyme at nanomolar concentrations. Some derivatives were also tested against RTs containing single amino acid mutations responsible for resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs). The different potencies displayed by the new compounds were studied using molecular modeling.
一系列新型苯并咪唑酮及其类似物被合成并评价为人类免疫缺陷病毒 1 型（HIV-1）抑制剂，其特征在于苯并咪唑酮环 N-1 位上的不同位置上存在一个或多个甲基或其他生物等排体。大多数新化合物在毫微微摩尔浓度下对 MT4 细胞中的 HIV-1 复制和 RT 酶具有高度抑制作用，同时细胞毒性最小。一些衍生物还针对含有导致对非核苷逆转录酶抑制剂（NNRTIs）耐药性的单个氨基酸突变的 RT 进行了测试。使用分子建模研究了新化合物的不同效力。
