招募停滞的 PriA DNA 解旋酶复制叉和复制体加载活性对于生存至关重要。
Recruitment to stalled replication forks of the PriA DNA helicase and replisome-loading activities is essential for survival.
机构信息
Molecular Biology Program, Weill-Cornell Graduate School of Medical Sciences, New York, NY, USA.
出版信息
DNA Repair (Amst). 2010 Mar 2;9(3):202-9. doi: 10.1016/j.dnarep.2009.12.009. Epub 2010 Jan 22.
Abstract
PriA, a 3'-->5' superfamily 2 DNA helicase, acts to remodel stalled replication forks and as a specificity factor for origin-independent assembly of a new replisome at the stalled fork. The ability of PriA to initiate replication at stalled forked structures ensures complete genome replication and helps to protect the cell from illegitimate recombination events. This review focuses on the activities of PriA and its role in replication fork assembly and maintaining genomic integrity.
摘要
PriA，一种 3'-->5' 超家族 2 DNA 解旋酶，作用是重塑停滞的复制叉，并作为在停滞的复制叉处组装新复制体的起点独立组装的特异性因素。PriA 启动停滞的分叉结构复制的能力可确保基因组的完全复制，并有助于防止细胞发生非同源重组事件。本文重点介绍 PriA 的活性及其在复制叉组装和维持基因组完整性中的作用。
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