Institut National de la Santé et de la Recherche Médicale (INSERM) U940, Hôpital Saint-Louis, Paris, France.
Transplantation. 2010 Jan 27;89(2):194-9. doi: 10.1097/TP.0b013e3181c3ca11.
The relevance of borderline change (BL) and subclinical cellular rejection (SCR) observed in renal transplantation remains to be determined. Several studies have shown in BL and SCR the presence of a Th1 immune response, qualitatively similar to but quantitatively reduced in comparison with infiltrates typical of acute cellular rejection (ACR).
To elucidate the role of regulatory T cells (Tregs) in the local control of the allogenic response, we studied their presence by immunohistochemistry in 24 biopsies with graft dysfunction (12 ACR and 12 BL) and in 16 protocol biopsies at 1 year (eight SCR and eight subclinical BL).
The proportion of Tregs in CD4 T infiltrates was higher in BL and SCR when compared with ACR. Moreover, their presence was correlated with the intensity of interstitial inflammation (r=-0.35, P=0.027, n=40) and with graft function at the time of the biopsy (r=-0.37, P=0.018, n=40).
These data suggest Treg recruitment at the acute phase of the allogenic response, where they could act to diminish the interstitial inflammation and its associated lesions.
在肾移植中观察到的边界变化 (BL) 和亚临床细胞性排斥反应 (SCR) 的相关性仍有待确定。几项研究表明，BL 和 SCR 中存在 Th1 免疫反应，其性质与急性细胞性排斥反应 (ACR) 的浸润相似，但数量减少。
为了阐明调节性 T 细胞 (Tregs) 在同种异体反应局部控制中的作用，我们通过免疫组织化学方法研究了 24 例移植功能障碍（12 例 ACR 和 12 例 BL）和 16 例 1 年时的方案活检（8 例 SCR 和 8 例亚临床 BL）中的 Tregs 的存在。
与 ACR 相比，BL 和 SCR 中 CD4 T 浸润中的 Treg 比例更高。此外，它们的存在与间质炎症的强度呈负相关（r=-0.35，P=0.027，n=40），与活检时的移植物功能呈负相关（r=-0.37，P=0.018，n=40）。
这些数据表明 Treg 在同种异体反应的急性期被募集，它们可能会减轻间质炎症及其相关病变。
