Visiting scholar, Department of Nutritional Sciences. Connecticut NIH EXPORT Center for Eliminating Health Disparities among Latinos. University of Connecticut. Storrs, CT 06269-4017, USA.
Nutr Res Pract. 2009 Winter;3(4):286-94. doi: 10.4162/nrp.2009.3.4.286. Epub 2009 Dec 31.
This study aimed to identify risk factors for type 2 diabetes (T2D) in Korea, a rapidly changing country. Data of 5,132 adults aged 20-85 were used from the 2001 Korean Health and Nutrition Examination Survey. Multiple logistic regression was carried out to identify risk factors for T2D. Three models were specified: (i) socioeconomic and demographic factors (model 1: age, gender, education, poverty income ratio, employment), (ii) behavioral risk factors and covariates (model 2: obesity, physical activity, smoking, alcohol drinking, dietary quality, family history of T2D, co-morbidity) and (iii) socioeconomic, demographic, and behavioral factors (model 3). The prevalence of T2D was 7.4%. Less education (OR 1.41, 95% CI 1.08-1.84), age (OR 2.19, 95% CI 1.56-3.08 in 40-59 yrs, OR 4.05, 95% CI 2.76-5.95 in 60 yrs + comparing to 20-39 yrs) and abdominal obesity (OR 2.24, 95% CI 1.79-2.82) were risk factors for T2D even after controlling for other factors simultaneously. There was a significant association of T2D with ever smoking (OR 1.34, 95% CI 1.06-1.67). The relationship of age with T2D was modified by gender in model 1 and the relationship of smoking with T2D was modified by obesity in model 2. Less educated, older, obese or ever smokers were more likely to have T2D. Gender mediated the relationship of age, and obesity mediated the relationship of smoking, with T2D. Intervention programs for T2D in Korea should take the interactions among risk factors into account.
本研究旨在确定韩国 2 型糖尿病（T2D）的风险因素，韩国是一个变化迅速的国家。本研究使用了 2001 年韩国健康与营养调查的 5132 名 20-85 岁成年人的数据。采用多因素逻辑回归分析确定 T2D 的危险因素。指定了三种模型：（i）社会经济和人口统计学因素（模型 1：年龄、性别、教育、贫困收入比、就业）；（ii）行为危险因素和协变量（模型 2：肥胖、体力活动、吸烟、饮酒、饮食质量、T2D 家族史、合并症）；（iii）社会经济、人口统计学和行为因素（模型 3）。T2D 的患病率为 7.4%。受教育程度较低（OR1.41，95%CI1.08-1.84）、年龄（40-59 岁 OR2.19，95%CI1.56-3.08；60 岁及以上 OR4.05，95%CI2.76-5.95，与 20-39 岁相比）和腹型肥胖（OR2.24，95%CI1.79-2.82）是 T2D 的危险因素，即使同时控制其他因素也是如此。T2D 与曾经吸烟显著相关（OR1.34，95%CI1.06-1.67）。在模型 1 中，性别对年龄与 T2D 的关系有修饰作用，在模型 2 中，肥胖对吸烟与 T2D 的关系有修饰作用。受教育程度较低、年龄较大、肥胖或曾经吸烟者更有可能患有 T2D。性别对年龄与 T2D 的关系起中介作用，肥胖对吸烟与 T2D 的关系起中介作用。韩国的 T2D 干预计划应考虑到危险因素之间的相互作用。
