Martinez R, Rietberg B, Skyler J, Oster J R, Perez G O
Medical Service, Veterans Administration Medical Center, Miami, Florida.
Experientia. 1991 Mar 15;47(3):270-2. doi: 10.1007/BF01958157.
The effect of hyperkalemia on insulin secretion remains undefined. We evaluated portal and peripheral insulin levels in anesthetized dogs after infusions of KCl. The mean maximal increase in peripheral plasma potassium at infusion rates of 0.2 mEq/kg/h was 0.68 +/- 0.20 mEq/l. There were no significant increases in either portal or peripheral insulin levels. In contrast, in six dogs whose plasma potassium concentration increased in each case by more than 2.0 mEq/l (infusion rate of 0.5 mEq/kg/h), portal insulin levels increased fivefold (p less than 0.05). We concluded that only marked increases in plasma potassium concentration stimulate pancreatic insulin secretion.
高钾血症对胰岛素分泌的影响尚不清楚。我们评估了在麻醉犬输注氯化钾后门静脉和外周血胰岛素水平。以0.2 mEq/kg/h的输注速率时，外周血浆钾平均最大增幅为0.68±0.20 mEq/l。门静脉或外周血胰岛素水平均无显著升高。相比之下，在6只血浆钾浓度每次均升高超过2.0 mEq/l（输注速率为0.5 mEq/kg/h）的犬中，门静脉胰岛素水平增加了五倍（p<0.05）。我们得出结论，只有血浆钾浓度的显著升高才会刺激胰腺胰岛素分泌。
