Ozuysal S, Bilgin T, Ozgur T, Celik N, Evrensel T
Uludag University School of Medicine, Department of Pathology, Bursa, Turkey.
Eur J Gynaecol Oncol. 2009;30(6):640-5.
To evaluate the expression of cyclooxygenase (COX)-2 in ovarian serous carcinomas (OSC) and its correlation with microvessel density (MVD), nm23 expression, clinicopathologic prognostic factors and survival.
Specimens from 44 patients with OSC were evaluated by immunohistochemistry for COX-2 and nm23 expression. Tumor MVD was assessed with CD34 immunostaining. The survival data of the patients were found from data files.
40 specimens (90.1%) showed positive COX-2 staining. Patients with high COX-2-expressed tumors had shorter overall survival, but it was not statistically significant. No correlation was found between COX-2 expression and clinicopathologic variables. There was no significant correlation between COX-2 and nm23 expression or MVD.
COX-2 is frequently expressed in OSC. Although we could not confirm the prognostic significance of Cox-2 expression in the present cohort of OSC patients, the p value for overall survival was just slightly greater than alpha, and this result can be referred as almost significant. We considered that the limited number of cases in our study might affect the statistical analysis of our results. Further studies involving a larger number of patients are needed to clarify the prognostic significance of COX-2 expression in ovarian carcinomas.
评估环氧化酶（COX）-2在卵巢浆液性癌（OSC）中的表达及其与微血管密度（MVD）、nm23表达、临床病理预后因素和生存率的相关性。
采用免疫组织化学方法检测44例OSC患者标本中COX-2和nm23的表达。用CD34免疫染色评估肿瘤MVD。从数据文件中获取患者的生存数据。
40例标本（90.1%）COX-2染色呈阳性。COX-2高表达肿瘤患者的总生存期较短，但差异无统计学意义。COX-2表达与临床病理变量之间无相关性。COX-2与nm23表达或MVD之间无显著相关性。
COX-2在OSC中经常表达。虽然在本队列的OSC患者中我们无法证实Cox-2表达的预后意义，但总生存期的P值仅略大于α，该结果可视为几乎具有显著性。我们认为本研究中病例数有限可能影响结果的统计分析。需要进一步开展涉及更多患者的研究以阐明COX-2表达在卵巢癌中的预后意义。
