Musiał Witold, Kokol Vanja, Voncina Bojana
University of Maribor, Department for Textile Materials and Design, Laboratory for Chemistry Dyes and Polymers, Slovenia.
Polim Med. 2009;39(4):15-24.
The aim of present work was preliminary assessment of the conductivity changes in aqueous compartment, consisting oflidocaine hydrochloride, and N-isopropylacrylamide derivative microgel, during increasing the temperature between 25 degrees and 42 degrees C, as a prerequisite to demonstrate the possibility of applying this microgel for pulsed release of lidocaine hydrochloride, when increased temperature is applied. Conductivity of respective systems composed of polymer and lidocaine hydrochloride were assigned as PNM I-LD, PNM II-LD, and PNM III-LD: obtained values were in the ranges: 39,91 microS/cm - 53,30 microS/cm in the 25 degrees C temperature, 46,14 microS/cm - 56,16 microS/cm in the temperature of 32 degrees C, and 53,30 microS/cm - 118,42 microS/cm at 42 degrees C. During heating or cooling of the microgels derivatives of N-isopropylacrylamide, there is possibility to obtain pulsed release of lidocaine hydrochloride from the polymeric bead in the range between 25 degrees C and 42 degrees C, according to the conductivity measurements.
本研究的目的是初步评估在25℃至42℃升温过程中，由盐酸利多卡因和N-异丙基丙烯酰胺衍生物微凝胶组成的水相中的电导率变化，以此作为证明当温度升高时应用这种微凝胶实现盐酸利多卡因脉冲释放可能性的前提条件。由聚合物和盐酸利多卡因组成的各个体系的电导率分别记为PNM I-LD、PNM II-LD和PNM III-LD：在25℃时获得的值范围为39.91 μS/cm至53.30 μS/cm，在32℃时为46.14 μS/cm至56.16 μS/cm，在42℃时为53.30 μS/cm至118.42 μS/cm。根据电导率测量结果，在加热或冷却N-异丙基丙烯酰胺微凝胶衍生物的过程中，有可能在25℃至42℃范围内从聚合物珠粒中实现盐酸利多卡因的脉冲释放。
