Coiro V, Volpi R, Capretti L, Speroni G, Castelli A, Chiodera P
Chair of Medical Clinic, University of Parma, School of Medicine, Italy.
Fertil Steril. 1991 Apr;55(4):712-6. doi: 10.1016/s0015-0282(16)54235-6.
Luteinizing hormone (LH) responses to gonadotropin-releasing hormone (GnRH) (100 micrograms injected intravenously (IV)) or naloxone (4 mg injected plus 8 mg infused in 2 hours IV) were evaluated in 29 women with insulin-dependent diabetes mellitus (IDDM) (duration, group I (n = 15): less than 10 years, range 3 to 9 years; group II (n = 14): greater than 10 years, range 11 to 20 years) and in 15 normal controls, on the 22nd days of normal menstrual cycles. Both GnRH- and naloxone-induced LH responses were similar in group I diabetics and normal controls, whereas they were significantly lower in group II than in group I diabetics or normal controls. Positive correlations were found between LH responses to GnRH and naloxone, whereas negative correlations were observed between maximal LH peaks in response to GnRH or naloxone and duration of diabetes. These data indicate that a hypothalamic pituitary disorder affects LH secretion with time after the onset of IDDM.
在29名胰岛素依赖型糖尿病（IDDM）女性（病程：I组（n = 15）：小于10年，范围3至9年；II组（n = 14）：大于10年，范围11至20年）和15名正常对照者的正常月经周期第22天，评估了促黄体生成素（LH）对促性腺激素释放激素（GnRH）（静脉注射（IV）100微克）或纳洛酮（静脉注射4毫克加在2小时内静脉输注8毫克）的反应。I组糖尿病患者和正常对照者中GnRH和纳洛酮诱导的LH反应相似，而II组的反应明显低于I组糖尿病患者或正常对照者。发现LH对GnRH和纳洛酮的反应之间存在正相关，而对GnRH或纳洛酮反应的最大LH峰值与糖尿病病程之间存在负相关。这些数据表明，IDDM发病后随着时间推移，下丘脑 - 垂体紊乱会影响LH分泌。
