典型哮喘患者中，支气管收缩引发的咳嗽功能受损。
Bronchoconstriction-triggered cough is impaired in typical asthmatics.
作者信息
Ohkura Noriyuki, Fujimura Masaki, Tokuda Akira, Nakade Yusuke, Nishitsuji Masaru, Abo Miki, Katayama Nobuyuki
机构信息
Respiratory Medicine, Kanazawa University Hospital, Ishikawa 920-8641, Japan.
出版信息
J Asthma. 2010 Feb;47(1):51-4. doi: 10.3109/02770900903362650.
BACKGROUND AND OBJECTIVE
Cough is an essential innate protective behavior, which is experienced by even healthy individuals. The mechanism of cough triggered by bronchoconstriction is not yet clear. The aim of this study was to investigate the relation between bronchoconstriction and cough caused by methacholine (Mch) inhalation in typical asthmatics and normal healthy subjects.
METHODS
We measured bronchial responsiveness to Mch and counted the number of coughs induced by Mch inhalation in 15 typical asthmatics and 20 normal subjects.
RESULTS
After inhalation of Mch at the concentration causing 20% or more decrease in forced expiratory volume in 1 second (FEV(1)) (PC(20)-FEV(1)), coughs were provoked in normal subjects (number of cough: 22.5/32 min, range: 3.3-45). Conversely, coughs were hardly provoked in typical asthmatics (median number of cough: 2/32 min, range: 0-4).
CONCLUSIONS
Although typical asthmatics have increased airway responsiveness, their cough response to bronchoconstriction is impaired.
背景与目的
咳嗽是一种重要的先天性保护行为，即使健康个体也会经历。支气管收缩引发咳嗽的机制尚不清楚。本研究旨在探讨典型哮喘患者和正常健康受试者中支气管收缩与吸入乙酰甲胆碱（Mch）引起的咳嗽之间的关系。
方法
我们测量了15名典型哮喘患者和20名正常受试者对Mch的支气管反应性，并计算了吸入Mch引起的咳嗽次数。
结果
吸入导致第一秒用力呼气量（FEV(1)）下降20%或更多的浓度的Mch（PC(20)-FEV(1)）后，正常受试者出现咳嗽（咳嗽次数：22.5/32分钟，范围：3.3-45）。相反，典型哮喘患者几乎不出现咳嗽（咳嗽次数中位数：2/32分钟，范围：0-4）。
结论
虽然典型哮喘患者气道反应性增加，但其对支气管收缩的咳嗽反应受损。
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