Department of Toxicology, Xinjiang Medical University, Urumqi, China.
Biomarkers. 2010 May;15(3):232-7. doi: 10.3109/13547500903444880.
To explore the association between polymorphism of vitamin D receptor (VDR) and lead poisoning in Uygur and Han children in China.
The BsmI, ApaI and TaqI restriction sites of VDR genotyping were determined by polymerase chain reaction-restriction fragment length polymorphism in 443 Uygur and 469 Han children from Xinjiang province. The correlation between the polymorphism of VDR haplotypes and blood lead levels was explored.
The genotype frequencies of VDR had significant differences in Han and Uygur children (p <0.01). According to VDR-BsmI, ApaI and TaqI haplotype analysis in Han children, haplotypes Atb and AtB were considerably decreased in the lead poisoning group (p <0.05) while haplotype aTb and ATb were significantly increased in the lead poisoning group (p <0.01). However, such results were not found in Uygur children (p < 0.05).
A significant difference was seen in the frequency distribution of the VDR genotype among the different races. Haplotypes Atb and AtB might be protective factors while haplotypes ATb and aTb might be risk factors in Han children.
探讨中国维吾尔族和汉族儿童维生素 D 受体（VDR）多态性与铅中毒的关系。
采用聚合酶链反应-限制性片段长度多态性方法，对来自新疆的 443 名维吾尔族儿童和 469 名汉族儿童的 VDR 基因分型 BsmI、ApaI 和 TaqI 限制性位点进行了检测。探讨了 VDR 单倍型多态性与血铅水平的相关性。
VDR 基因型频率在汉族和维吾尔族儿童中存在显著差异（p<0.01）。根据汉族儿童 VDR-BsmI、ApaI 和 TaqI 单倍型分析，铅中毒组 Atb 和 AtB 单倍型明显减少（p<0.05），而铅中毒组 aTb 和 ATb 单倍型显著增加（p<0.01）。然而，在维吾尔族儿童中并未发现这些结果（p<0.05）。
不同种族之间 VDR 基因型的频率分布存在显著差异。在汉族儿童中，Atb 和 AtB 单倍型可能是保护因素，而 ATb 和 aTb 单倍型可能是危险因素。
