细胞内膜氯离子通道。
Chloride channels of intracellular membranes.
机构信息
UNC Kidney Center and the Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, USA.
出版信息
FEBS Lett. 2010 May 17;584(10):2102-11. doi: 10.1016/j.febslet.2010.01.037. Epub 2010 Jan 26.
Abstract
Proteins implicated as intracellular chloride channels include the intracellular ClC proteins, the bestrophins, the cystic fibrosis transmembrane conductance regulator, the CLICs, and the recently described Golgi pH regulator. This paper examines current hypotheses regarding roles of intracellular chloride channels and reviews the evidence supporting a role in intracellular chloride transport for each of these proteins.
摘要
被认为是细胞内氯离子通道的蛋白质包括细胞内 ClC 蛋白、Bestrophin 家族蛋白、囊性纤维化跨膜电导调节因子、CLICs 蛋白以及最近描述的高尔基 pH 调节剂。本文探讨了关于细胞内氯离子通道作用的现有假说，并回顾了支持这些蛋白质在细胞内氯离子转运中发挥作用的证据。
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本文引用的文献
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ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel.内质网定位的 bestrophin 1 可能作为抗衡离子通道，通过激活 Ca2+依赖性离子通道 TMEM16A 和 SK4 而发挥作用。
Pflugers Arch. 2010 Feb;459(3):485-97. doi: 10.1007/s00424-009-0745-0. Epub 2009 Oct 13.
2
Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions.具有不同功能的贝斯特罗芬和跨膜蛋白16钙离子激活氯离子通道。
Cell Calcium. 2009 Oct;46(4):233-41. doi: 10.1016/j.ceca.2009.09.003. Epub 2009 Sep 26.
3
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Mol Biol Cell. 2009 Nov;20(22):4664-72. doi: 10.1091/mbc.e09-06-0529. Epub 2009 Sep 23.
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Nat Cell Biol. 2009 Jun;11(6):777-84. doi: 10.1038/ncb1885. Epub 2009 May 17.
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