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细胞内膜氯离子通道。

Chloride channels of intracellular membranes.

机构信息

UNC Kidney Center and the Division of Nephrology and Hypertension, Department of Medicine, University of North Carolina at Chapel Hill, USA.

出版信息

FEBS Lett. 2010 May 17;584(10):2102-11. doi: 10.1016/j.febslet.2010.01.037. Epub 2010 Jan 26.

DOI:10.1016/j.febslet.2010.01.037
PMID:20100480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2929963/
Abstract

Proteins implicated as intracellular chloride channels include the intracellular ClC proteins, the bestrophins, the cystic fibrosis transmembrane conductance regulator, the CLICs, and the recently described Golgi pH regulator. This paper examines current hypotheses regarding roles of intracellular chloride channels and reviews the evidence supporting a role in intracellular chloride transport for each of these proteins.

摘要

被认为是细胞内氯离子通道的蛋白质包括细胞内 ClC 蛋白、Bestrophin 家族蛋白、囊性纤维化跨膜电导调节因子、CLICs 蛋白以及最近描述的高尔基 pH 调节剂。本文探讨了关于细胞内氯离子通道作用的现有假说，并回顾了支持这些蛋白质在细胞内氯离子转运中发挥作用的证据。

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2
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本文引用的文献

1
ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel.内质网定位的 bestrophin 1 可能作为抗衡离子通道，通过激活 Ca2+依赖性离子通道 TMEM16A 和 SK4 而发挥作用。
Pflugers Arch. 2010 Feb;459(3):485-97. doi: 10.1007/s00424-009-0745-0. Epub 2009 Oct 13.
2
Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions.具有不同功能的贝斯特罗芬和跨膜蛋白16钙离子激活氯离子通道。
Cell Calcium. 2009 Oct;46(4):233-41. doi: 10.1016/j.ceca.2009.09.003. Epub 2009 Sep 26.
3
Spatiotemporal regulation of chloride intracellular channel protein CLIC4 by RhoA.RhoA 对氯离子通道蛋白 CLIC4 的时空调节。
Mol Biol Cell. 2009 Nov;20(22):4664-72. doi: 10.1091/mbc.e09-06-0529. Epub 2009 Sep 23.
4
TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3.转化生长因子-β信号传导由CLIC4依赖Schnurri-2的核转位以及随后磷酸化的Smad2和Smad3的稳定所调节。
Nat Cell Biol. 2009 Jun;11(6):777-84. doi: 10.1038/ncb1885. Epub 2009 May 17.
5
Revisiting the role of cystic fibrosis transmembrane conductance regulator and counterion permeability in the pH regulation of endocytic organelles.重新审视囊性纤维化跨膜传导调节因子和抗衡离子通透性在内吞细胞器pH调节中的作用。
Mol Biol Cell. 2009 Jul;20(13):3125-41. doi: 10.1091/mbc.e09-01-0061. Epub 2009 May 6.
6
An essential role for ClC-4 in transferrin receptor function revealed in studies of fibroblasts derived from Clcn4-null mice.在对源自Clcn4基因敲除小鼠的成纤维细胞的研究中揭示了ClC-4在转铁蛋白受体功能中的重要作用。
J Cell Sci. 2009 Apr 15;122(Pt 8):1229-37. doi: 10.1242/jcs.037317.
7
Defective organellar acidification as a cause of cystic fibrosis lung disease: reexamination of a recurring hypothesis.细胞器酸化缺陷作为囊性纤维化肺病的一个病因：对一个反复出现的假说的重新审视。
Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L859-67. doi: 10.1152/ajplung.00018.2009. Epub 2009 Mar 27.
8
Physiological implications of the regulation of vacuolar H+-ATPase by chloride ions.氯离子对液泡H⁺-ATP酶调节的生理意义。
Braz J Med Biol Res. 2009 Feb;42(2):155-63. doi: 10.1590/s0100-879x2009000200002.
9
Chloride intracellular channel 4 is involved in endothelial proliferation and morphogenesis in vitro.氯离子细胞内通道 4 参与体外血管内皮细胞的增殖和形态发生。
Angiogenesis. 2009;12(3):209-20. doi: 10.1007/s10456-009-9139-3. Epub 2009 Feb 27.
10
Chloride intracellular channel protein-4 functions in angiogenesis by supporting acidification of vacuoles along the intracellular tubulogenic pathway.氯离子细胞内通道蛋白4通过支持沿细胞内管状发生途径的液泡酸化在血管生成中发挥作用。
Am J Pathol. 2009 Mar;174(3):1084-96. doi: 10.2353/ajpath.2009.080625. Epub 2009 Feb 5.