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经卵胞浆内单精子注射技术生育健康婴儿:1 例卡他性支气管扩张综合征患者的精液分析及临床治疗

A healthy birth after intracytoplasmic sperm injection using ejaculated spermatozoa from a patient with Kartagener's syndrome.

机构信息

Hanabusa Women's Clinic, Chuo-Ku, Kobe, Japan.

出版信息

Fertil Steril. 2010 Apr;93(6):2074.e17-9. doi: 10.1016/j.fertnstert.2009.11.042. Epub 2010 Jan 25.

Abstract

OBJECTIVE

To report a healthy birth that was achieved by intracytoplasmic sperm injection (ICSI) with use of ejaculated spermatozoa from a patient with Kartagener's syndrome.

DESIGN

Case report.

SETTING

Private infertility clinic.

PATIENT(S): Couple with male factor infertility due to Kartagener's syndrome.

INTERVENTION(S): Intracytoplasmic sperm injection with ejaculated sperm.

MAIN OUTCOME MEASURE(S): Semen characteristics, sperm motility, fertilization, pregnancy, and birth after ICSI.

RESULT(S): With ejaculated sperm, the fertilization rates were 73% in the first stimulation cycle and 100% in the second cycle. Intracytoplasmic sperm injection was successful. The pregnancy resulted in birth of a single healthy child.

CONCLUSION(S): With ejaculated sperm, successful pregnancy after ICSI in couples with Kartagener's syndrome is possible. Kartagener's syndrome is a heterogeneous group of disorders with similar clinical presentations, and treatment should be individualized depending on sperm motility.

摘要

目的

报告一例通过使用患有卡他性综合征患者的射出精液进行卵胞浆内单精子注射(ICSI)而实现的健康分娩。

设计

病例报告。

地点

私人不孕诊所。

患者

因卡他性综合征导致男性因素不孕的夫妇。

干预

使用射出精液进行卵胞浆内单精子注射。

主要观察指标

精液特征、精子活力、受精、妊娠和 ICSI 后的分娩。

结果

在第一次刺激周期中,使用射出精液的受精率为 73%,在第二次周期中达到 100%。卵胞浆内单精子注射成功。妊娠导致单胎健康婴儿的出生。

结论

对于患有卡他性综合征的夫妇,使用射出精液进行 ICSI 后可以成功妊娠。卡他性综合征是一组具有相似临床表现的异质性疾病,治疗应根据精子活力进行个体化。

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