Birth of a healthy boy using fresh testicular sperm in a patient with Klinefelter syndrome combined with Kartagener syndrome.

OBJECTIVE

To report a case of Klinefelter syndrome combined with Kartagener syndrome.

DESIGN

Case report.

SETTING

Private IVF center.

PATIENT(S): A 35-year-old man with Klinefelter syndrome combined with Kartagener syndrome causing primary infertility.

INTERVENTION(S): Testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI).

MAIN OUTCOME MEASURE(S): Sperm recovery, fertilization, and live birth.

RESULT(S): Ovulation induction of the female partner, recovery of spermatozoa by TESE from the male partner and ICSI of 9 metaphase II oocytes resulted in two fertilized oocytes. The delivery of a healthy boy with normal anatomy and 46,XY karyotype was achieved after the transfer of only one 4-cell grade 1 embryo.

CONCLUSION(S): To our knowledge, this case with nonmosaic Klinefelter syndrome combined with Kartagener's syndrome is unique and demonstrates the revolutionary aspects of assisted reproductive technologies (ART) concerning male factor infertility.