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[对具有耐药性细菌的肺结核进行临床、放射学和细菌学研究]

[Clinical, radiological and bacteriological study of pulmonary tuberculosis with bacteria showing drug resistance].

作者信息

Albu A, Hartia V, Esrig E, Galbenu M, Marcovici M, Gălculescu A, Golub M

出版信息

Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Pneumoftiziol. 1977 Jul-Sep;26(3):151-60.

PMID:201007
Abstract

The authors have investigated two groups of patients of young age suffering from tuberculosis with germs showing primary resistance to chemotherapeutic agents (61 cases), and with germs displaying sensitivity to these agents (64 cases). The following conclusions have been reached: tuberculosis with germs showing primary drug resistance did not display onset modalities, clinically and radiologically, that differed significantly from other types of tuberculosis; sputum conversion is more slow in patients with resistant germs than in those with sensitive germs in the first two months of treatment, but following application of the treatment according to the data resulting from the antibiogram, this differences quickly disappeared. The presence of a smaller number of complete recoveries and of a surplus of doubtful recoveries can be explained in the same way in this group of patients: the final results are similar in both groups of patients, evidencing that the treatment of pulmonary tuberculosis due to germs showing parimary drug resistance does not give rise to particular problems.

摘要

作者对两组年轻的结核病患者进行了调查,一组患者的结核病菌对化疗药物表现出原发性耐药(61例),另一组患者的结核病菌对这些药物敏感(64例)。得出以下结论:具有原发性耐药病菌的结核病在临床和放射学上的发病方式与其他类型的结核病没有显著差异;在治疗的头两个月,耐药病菌患者的痰菌转阴比敏感病菌患者更慢,但根据药敏试验结果应用治疗后,这种差异很快消失。在这组患者中,完全康复的人数较少和可疑康复的人数较多可以用同样的方式解释:两组患者的最终结果相似,表明由原发性耐药病菌引起的肺结核治疗不会产生特殊问题。

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