Nano-Oriented Bio-Electronics Lab, Department of Electrical Engineering, College of Information Science & Technology, KAIST, Daejeon 305-701, Korea.
Nanotechnology. 2010 Feb 26;21(8):85303. doi: 10.1088/0957-4484/21/8/085303. Epub 2010 Jan 26.
A novel microelectrode modification method is reported for neural electrode engineering with a flake nanostructure (nanoflake). The nanoflake-modified electrodes are fabricated by combining conventional lithography and electrochemical deposition to implement a microelectrode array (MEA) on a glass substrate. The unique geometrical properties of nanoflake sharp tips and valleys are studied by optical, electrochemical and electrical methods in order to verify the advantages of using nanoflakes for neural recording devices. The in vitro recording and stimulation of cultured hippocampal neurons are demonstrated on the nanoflake-modified MEA and the clear action potentials are observed due to the nanoflake impedance reduction effect.
报道了一种用于神经电极工程的新型微电极修饰方法，该方法采用片状纳米结构（纳米片）。通过结合传统光刻和电化学沉积，在玻璃衬底上制造了纳米片修饰电极，以实现微电极阵列（MEA）。通过光学、电化学和电学方法研究了纳米片尖锐尖端和凹陷的独特几何特性，以验证使用纳米片用于神经记录装置的优势。在纳米片修饰的 MEA 上进行了培养的海马神经元的体外记录和刺激，由于纳米片的阻抗降低效应，观察到了清晰的动作电位。
