Department of Health Sciences, Mid Sweden University, SE-851 70 Sundsvall, Sweden.
Scand J Work Environ Health. 2010 Mar;36(2):85-95. doi: 10.5271/sjweh.2897. Epub 2010 Jan 26.
Our aim was to review published literature on the association between shift work and gastrointestinal (GI) disorders.
A systematic review of the literature was conducted of studies that have reported GI symptoms and diseases among shift workers. We used Medline to search for articles from 1966-2009. Next, we manually searched articles in the reference list of each article and previous reviews.
Twenty studies met the inclusion criteria. Four of six studies showed a significant association between shift work and GI symptoms, and five of six studies reported an association between shift work and peptic ulcer disease. Two of three studies showed an association between shift work and functional GI disease. Only a few studies have examined gastroesophageal reflux disease, chronic inflammatory bowel diseases, or GI cancers in relation to shift work.
Our general judgment is that shift workers appear to have increased risk of GI symptoms and peptic ulcer disease. However, control for potential confounders (eg, smoking, age, socioeconomic status, and other risk factors) was often lacking or insufficient in many of the studies we examined.
我们旨在回顾有关轮班工作与胃肠道（GI）疾病之间关联的已发表文献。
对报告轮班工作者 GI 症状和疾病的研究进行了系统的文献回顾。我们使用 Medline 检索了 1966 年至 2009 年的文章。然后，我们手动查阅了每篇文章和先前综述的参考文献列表中的文章。
有 20 项研究符合纳入标准。6 项研究中的 4 项表明轮班工作与 GI 症状之间存在显著关联，6 项研究中的 5 项报告轮班工作与消化性溃疡病之间存在关联。3 项研究中的 2 项表明轮班工作与功能性 GI 疾病之间存在关联。只有少数研究检查了与轮班工作相关的胃食管反流病、慢性炎症性肠病或胃肠道癌症。
我们的总体判断是，轮班工作者似乎有更高的 GI 症状和消化性溃疡病风险。然而，我们检查的许多研究中，往往缺乏或不足以控制潜在的混杂因素（如吸烟、年龄、社会经济地位和其他危险因素）。
