Kellokumpu-Lehtinen Pirkko-Liisa, Puistola Ulla, Paija Outi, Taimela Eeva, Hirvonen Outi, Raassina Sari, Riska Henrik
Department of Oncology, University of Tampere and Tampere University Hospital, B.O.X. 607, FIN 33101, Tampere, Finland.
Support Care Cancer. 2011 Jan;19(1):149-53. doi: 10.1007/s00520-009-0809-x. Epub 2010 Jan 26.
Anaemia is very frequently diagnosed among cancer patients. Use of erythropoietins has proved to be effective in reducing the need of transfusions and enhancing patients' quality of life, but may also have detrimental effects in treating nonanemic asymptomatic patients. We assessed the frequency of anaemia and the frequency with which it was diagnosed and treated in different types of solid tumours treated at outpatient chemotherapy policlinics.
During the study period, altogether 733 consecutive subjects received chemotherapy at the five Finnish University Hospitals. Their data were collected. The physician who was responsible for the chemotherapy treatment was unaware of the survey. The response to anaemia (treated or not, the modality of treatment) were established from patients records; 69% were females, mean age was 61 years (range, 24-92).
The median haemoglobin level was 12.7 g/dL (range, 8.9-15.5 g/dL). About one third of the patients (200/733, 27%) had a value less than 12 g/dL. In only 15% of these cases was there any documentation of response or a possible treatment option for anaemia. On the other hand, only 12% of all patients (N=91) had a haemoglobin value less than 11 g/dL. However, in most of them anaemia had not been considered; in only 25% of cases was an active treatment option selected.
According to our survey, anaemia was less common in our patients than in the European Cancer Anaemia Survey. Only a minority of chemotherapy patients receiving their treatments as outpatients would need active treatment for their anaemia.
贫血在癌症患者中极为常见。已证明使用促红细胞生成素在减少输血需求和提高患者生活质量方面是有效的,但在治疗非贫血无症状患者时可能也有不利影响。我们评估了在门诊化疗门诊接受治疗的不同类型实体瘤患者中贫血的发生率以及其被诊断和治疗的频率。
在研究期间,共有733名连续的受试者在五家芬兰大学医院接受化疗。收集了他们的数据。负责化疗治疗的医生对调查不知情。从患者记录中确定对贫血的反应(是否接受治疗、治疗方式);69%为女性,平均年龄为61岁(范围24 - 92岁)。
血红蛋白水平中位数为12.7 g/dL(范围8.9 - 15.5 g/dL)。约三分之一的患者(200/733,27%)血红蛋白值低于12 g/dL。在这些病例中,仅有15%有关于贫血反应或可能治疗方案的记录。另一方面,所有患者中仅有12%(N = 91)血红蛋白值低于11 g/dL。然而,其中大多数患者未被考虑有贫血;仅有25%的病例选择了积极的治疗方案。
根据我们的调查,我们的患者中贫血比欧洲癌症贫血调查中的情况少见。仅少数接受门诊化疗的患者需要对其贫血进行积极治疗。