Jacobi C, Lenhard T, Meyding-Lamadé U
Neurologische Klinik, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, Heidelberg, Germany.
Nervenarzt. 2010 Feb;81(2):172-80. doi: 10.1007/s00115-009-2896-9.
Vasculitis and vasculopathies of the central and peripheral nervous system can be caused by infectious diseases. Vasculitis can lead to stenosis, occlusion and aneurysm formation of blood vessels which may result in stroke or cerebral haemorrhage. In cases of peripheral nervous system involvement mononeuritis multiplex and symmetric peripheral neuropathy are possible. The diagnosis is based on clinical presentation, serology, cerebrospinal fluid analysis and neuroradiologic examinations. In cases of peripheral neuropathy neurophysiologic examinations and biopsy of the sural nerve can lead to the diagnosis. A fast and efficient antimicrobial therapy is the most important treatment option. In cases of peripheral neuropathies short-term treatment with corticosteroids and plasma exchange may be helpful.
中枢和周围神经系统的血管炎及血管病变可能由传染病引起。血管炎可导致血管狭窄、闭塞和动脉瘤形成,进而可能引发中风或脑出血。在外周神经系统受累的情况下,可能出现多发性单神经炎和对称性周围神经病。诊断基于临床表现、血清学、脑脊液分析和神经放射学检查。对于周围神经病,神经生理学检查和腓肠神经活检可得出诊断。快速有效的抗菌治疗是最重要的治疗选择。对于周围神经病,短期使用皮质类固醇和血浆置换可能会有帮助。