Mörike K, Sindermann J R
Institute of Experimental and Clinical Pharmacology and Toxicology, Department of Clinical Pharmacology, University Hospital Tuebingen, Otfried-Müller-Strasse 45, Tuebingen, Germany.
Thorac Cardiovasc Surg. 2010 Feb;58 Suppl 2:S170-2. doi: 10.1055/s-0029-1240711. Epub 2010 Jan 25.
Drug treatment of chronic systolic heart failure usually includes angiotensin-converting enzyme inhibitor, or an angiotensin II receptor blocker, and a beta blocker, as prognostic benefit of these agents has been demonstrated in a large body of clinical trials. Depending on the stage of the disease and concomitant factors, an aldosterone antagonist and/or a digitalis glycoside may provide additional benefit. Most patients also receive a diuretic for symptomatic relief. Conversely, some drugs may precipitate or aggravate chronic systolic heart failure.
慢性收缩性心力衰竭的药物治疗通常包括血管紧张素转换酶抑制剂或血管紧张素 II 受体阻滞剂以及β受体阻滞剂，因为大量临床试验已证明这些药物具有预后益处。根据疾病阶段和伴随因素，醛固酮拮抗剂和/或洋地黄糖苷可能会带来额外益处。大多数患者还会使用利尿剂来缓解症状。相反，一些药物可能会诱发或加重慢性收缩性心力衰竭。
