阿尔茨海默病中 ACAT1 介导的神经元胆固醇酯化作用。
Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease.
机构信息
Department of Biochemistry, Dartmouth Medical School, Hanover, NH 03755, USA.
出版信息
IUBMB Life. 2010 Apr;62(4):261-7. doi: 10.1002/iub.305.
DOI:10.1002/iub.305
PMID:20101629
Abstract
Cholesterol has been implicated in various neurodegenerative diseases. Here we review the connection between cholesterol and Alzheimer's disease (AD), focusing on a recent study that links neuronal cholesterol esterification with biosynthesis of 24(S)-hydroxycholesterol and the fate of human amyloid precursor protein in a mouse model of AD. We also briefly evaluate the potential of ACAT1 as a drug target for AD.
摘要
胆固醇与各种神经退行性疾病有关。本文综述了胆固醇与阿尔茨海默病（AD）的关系，重点介绍了最近的一项研究，该研究将神经元胆固醇酯化与 24(S)-羟基胆固醇的生物合成以及 AD 小鼠模型中人淀粉样前体蛋白的命运联系起来。我们还简要评估了 ACAT1 作为 AD 药物靶点的潜力。
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