Dapper I, Nauwynck M, Selleslag D, Hidajat M, Bourgeois M, Martens P, Wilmer A
Intensive Care Unit, AZ Monica, Antwerpen, Belgium.
Acta Clin Belg. 2009 Nov-Dec;64(6):517-9. doi: 10.1179/acb.2009.088.
We report a case of haemolytic due to the use of piperacillin-tazobactam in a 50-year-old woman. Since 2002 4 other cases were reported. Either the presence of piperacillin as tazobactam can induce haemolysis. In all cases discontinuating the drugs resolves the haemolysis. Although drug-induced haemolytic anaemia due to piperacillin-tazobactam is rare, the common use of this antibioticum in the critical care setting should alert the physician as a possible culprit in cases of haemolytic anaemia.
我们报告了一例50岁女性因使用哌拉西林-他唑巴坦导致溶血的病例。自2002年以来，另有4例病例被报道。哌拉西林或他唑巴坦的存在均可能诱发溶血。在所有病例中，停用药物可使溶血症状消退。尽管哌拉西林-他唑巴坦所致的药物性溶血性贫血较为罕见，但在重症监护环境中这种抗生素的广泛使用应提醒医生，在溶血性贫血病例中它可能是一个潜在病因。
