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1
Pin1 as an anticancer drug target.
Drug News Perspect. 2009 Sep;22(7):399-407. doi: 10.1358/dnp.2009.22.7.1381751.
2
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Curr Cancer Drug Targets. 2008 May;8(3):223-9. doi: 10.2174/156800908784293622.
3
A phosphorylated prodrug for the inhibition of Pin1.
Bioorg Med Chem Lett. 2007 Dec 1;17(23):6615-8. doi: 10.1016/j.bmcl.2007.09.073. Epub 2007 Sep 26.
4
The methyl group as a source of structural diversity in heterocyclic chemistry: side chain functionalization of picolines and related heterocycles.
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5
Structural basis for high-affinity peptide inhibition of human Pin1.
ACS Chem Biol. 2007 May 22;2(5):320-8. doi: 10.1021/cb7000044.
6
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7
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8
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9
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10
Peptidyl-prolyl isomerase inhibitors.
Biopolymers. 2006;84(2):125-46. doi: 10.1002/bip.20240.
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