钯(II)催化的杂芳烃的氧化 C-H/C-H 交叉偶联。
Palladium(II)-catalyzed oxidative C-H/C-H cross-coupling of heteroarenes.
机构信息
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China.
出版信息
J Am Chem Soc. 2010 Feb 17;132(6):1822-4. doi: 10.1021/ja909807f.
An efficient methodology for the synthesis of unsymmetrical biheteroaryl molecules has been developed via Pd(II)-catalyzed oxidative C-H/C-H cross-coupling of heteroarenes. An inversion in reactivity and selectivity has been achieved successfully to perform the desired heterocoupling. This process allows the heterocoupling of not only electron-rich N-containing heteroarenes (e.g., xanthines, azoles, and indolizines) but also electron-poor pyridine N-oxides with various thiophenes or furans.
已开发出一种通过 Pd(II)催化的杂芳烃氧化 C-H/C-H 交叉偶联反应来合成不对称双杂芳基分子的有效方法。通过成功实现所需的杂偶联，成功地反转了反应性和选择性。该过程不仅允许富电子含氮杂芳烃（例如嘌呤、唑和吲哚嗪）与各种噻吩或呋喃进行杂偶联，还允许贫电子吡啶 N-氧化物与各种噻吩或呋喃进行杂偶联。
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