普芦卡必利治疗便秘。
Prucalopride for constipation.
机构信息
Clinical Enteric Neuroscience Translational and Epidemiological Research (C.E.N.T.E.R.), College of Medicine, Mayo Clinic, Charlton 8-110, 200 First St S.W., Rochester, MN 55905, USA.
出版信息
Expert Opin Pharmacother. 2010 Feb;11(3):451-61. doi: 10.1517/14656560903567057.
IMPORTANCE OF THE FIELD
Chronic constipation has a high prevalence, and current medical and pharmacological therapies do not restore normal bowel function in all patients.
AREAS COVERED IN THE REVIEW
A PubMed search (1965 - 2009) using the following terms alone or in combination: prucalopride, 5-HT(4), R093877, safety, toxicity, pharmacokinetics, pharmacodynamics, transit, cardiac, hERG, arrhythmia, potassium current, elderly.
WHAT THE READER WILL GAIN
Understanding of the mechanisms of action, safety, efficacy and indications for prucalopride in patients with chronic constipation.
TAKE HOME MESSAGE
Prucalopride is an efficacious and generally safe, new therapeutic option in the management of chronic constipation.
重要性的领域
慢性便秘的患病率很高，目前的医学和药物治疗并不能使所有患者的肠道功能恢复正常。
审查范围
一个 PubMed 搜索（1965 年-2009 年）使用以下术语单独或组合：普芦卡必利，5-HT（4），R093877，安全性，毒性，药代动力学，药效学，传输，心脏，hERG，心律失常，钾电流，老年人。
读者将获得
了解普芦卡必利在慢性便秘患者中的作用机制、安全性、疗效和适应证。
带回家的信息
普芦卡必利是一种有效的、通常安全的新的治疗选择，用于治疗慢性便秘。
Zotero 插件