Department of Experimental and Clinical Physiology, Medical University of Warsaw, Warsaw, Poland.
Stress. 2009 Nov;12(6):517-25. doi: 10.3109/10253890802687688.
The present study was aimed at determining the role of centrally released oxytocin in regulation of blood pressure and heart rate (HR) under resting conditions and during an acute air-jet stress in rats with a myocardial infarction and controls infarcted. Four weeks after ligation of a coronary artery or sham surgery, conscious Sprague Dawley rats were subjected to one of the following intracerebroventricular (ICV) infusions: (1) 0.9% NaCl (control), (2) oxytocin, (3) oxytocin receptor antagonist {desGly-NH(2)-d(CH(2))(5)[D-Tyr(2)Thr(4)]OVT}(OXYANT). Resting arterial blood pressure and HR were not affected by any of the ICV infusions either in the infarcted or sham-operated rats. In the control experiments, the pressor and tachycardic responses to the air jet of infarcted rats were significantly greater than in the sham-operated rats. OXYANT significantly enhanced the cardiovascular responses to stress only in the sham-operated rats whereas oxytocin significantly attenuated both responses in the infarcted but not in the sham-operated rats. The results suggest that centrally released endogenous oxytocin significantly reduces the cardiovascular responses to the acute stressor in control rats. This buffering function of the brain-oxytocin system is not efficient during the post-myocardial infarction state, however it may be restored by central administration of exogenous oxytocin.
本研究旨在确定在心肌梗死大鼠和对照组中，中枢释放的催产素在调节静息状态下和急性空气喷射应激时的血压和心率（HR）中的作用。在冠状动脉结扎或假手术后 4 周，将清醒的 Sprague Dawley 大鼠进行以下一种脑室内（ICV）输注：（1）0.9%NaCl（对照），（2）催产素，（3）催产素受体拮抗剂{desGly-NH(2)-d(CH(2))(5)[D-Tyr(2)Thr(4)]OVT}(OXYANT)。在梗死或假手术大鼠中，任何 ICV 输注均不影响静息动脉血压和 HR。在对照实验中，与假手术大鼠相比，空气喷射引起的梗死大鼠的升压和心动过速反应明显更大。OXYANT 仅在假手术大鼠中显著增强了对压力的心血管反应，而催产素则显著减弱了梗死大鼠的这两种反应，但对假手术大鼠无影响。结果表明，中枢释放的内源性催产素显著降低了对照组大鼠对急性应激源的心血管反应。然而，在心肌梗死后状态下，这种脑-催产素系统的缓冲功能效率较低，但通过中枢给予外源性催产素可以恢复。
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