心血管神经内分泌学：神经垂体激素在病理生理学中的新作用。
Cardiovascular Neuroendocrinology: Emerging Role for Neurohypophyseal Hormones in Pathophysiology.
机构信息
Department of Physiology and Anatomy, Graduate School of Biomedical Sciences, UNT Health Science Center, Fort Worth, TX 76107, USA.
Texas College of Osteopathic Medicine, UNT Health Science Center, Fort Worth, TX 76107, USA.
出版信息
Endocrinology. 2021 Aug 1;162(8). doi: 10.1210/endocr/bqab082.
Abstract
Arginine vasopressin (AVP) and oxytocin (OXY) are released by magnocellular neurosecretory cells that project to the posterior pituitary. While AVP and OXY currently receive more attention for their contributions to affiliative behavior, this mini-review discusses their roles in cardiovascular function broadly defined to include indirect effects that influence cardiovascular function. The traditional view is that neither AVP nor OXY contributes to basal cardiovascular function, although some recent studies suggest that this position might be re-evaluated. More evidence indicates that adaptations and neuroplasticity of AVP and OXY neurons contribute to cardiovascular pathophysiology.
摘要
精氨酸加压素 (AVP) 和催产素 (OXY) 由投射到垂体后叶的大细胞神经分泌细胞释放。虽然 AVP 和 OXY 目前因其对亲和行为的贡献而受到更多关注，但本综述广泛讨论了它们在心血管功能中的作用，包括影响心血管功能的间接影响。传统观点认为，AVP 和 OXY 都不参与基础心血管功能，尽管最近的一些研究表明可能需要重新评估这一观点。更多的证据表明，AVP 和 OXY 神经元的适应性和神经可塑性有助于心血管病理生理学。
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