Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA.
Ann Thorac Surg. 2010 Feb;89(2):459-64. doi: 10.1016/j.athoracsur.2009.10.065.
Left ventricular outflow tract obstruction may be unmasked after a successful aortic valve replacement (AVR) for severe aortic stenosis in the setting of asymmetrical basal septal hypertrophy (ABSH). The quantitative assessment of the obstructive potential of ABSH adjacent to a severely stenotic valve can be challenging. We reviewed our experience with patients who underwent concomitant septal myectomy at the time of AVR for severe aortic stenosis.
During the 10-year period ending January 2009, 3,523 patients underwent AVR for the primary indication of severe aortic stenosis. Forty-seven of these patients underwent concomitant septal myectomy. Preoperative and postoperative echocardiograms, operative data, hospital course, morbidity, and mortality were assessed.
The mean age of the group was 73 +/- 11 years. The mean aortic valve area was 0.74 cm(2) preoperatively. On preoperative transthoracic echocardiography, only 28% of the patients were considered to be at risk for possible left ventricular outflow tract obstruction. The mean left ventricular mass index decreased from 113.7 +/- 24.3 g preoperatively to 90.0 +/- 17.2 g at 1 year after the surgery (p < 0.001). The operative mortality was 2%. Complete heart block was observed in 2 patients (4.2%), and no iatrogenic ventricular septal defect was noted.
A quantitative assessment of the obstructive ABSH in the setting of severe aortic stenosis may be difficult preoperatively. Surgeons should inspect left ventricular outflow tract for possible obstructive ABSH at the time of AVR. Concomitant myectomy is a safe and effective procedure without additional complications and should be considered for patients with a preoperative or intraoperative diagnosis of ABSH even though dynamic obstruction was not demonstrated.
在严重主动脉瓣狭窄患者成功进行主动脉瓣置换(AVR)后,不对称性基底间隔肥厚(ABSH)可能会导致左心室流出道梗阻。评估紧邻严重狭窄瓣膜的 ABSH 的潜在梗阻性可能具有挑战性。我们回顾了在严重主动脉瓣狭窄患者接受 AVR 时同时进行间隔心肌切除术的患者的经验。
在 2009 年 1 月结束的 10 年期间,3523 例患者因严重主动脉瓣狭窄的主要指征接受了 AVR。其中 47 例患者接受了同期的间隔心肌切除术。评估了术前和术后超声心动图、手术数据、住院过程、发病率和死亡率。
该组的平均年龄为 73 +/- 11 岁。术前主动脉瓣口面积为 0.74 cm(2)。术前经胸超声心动图仅 28%的患者被认为存在可能的左心室流出道梗阻风险。左心室质量指数从术前的 113.7 +/- 24.3 g 降至术后 1 年的 90.0 +/- 17.2 g(p < 0.001)。手术死亡率为 2%。2 例(4.2%)患者出现完全性心脏传导阻滞,未发现医源性室间隔缺损。
在严重主动脉瓣狭窄的情况下,对梗阻性 ABSH 的定量评估可能在术前较为困难。外科医生在进行 AVR 时应检查左心室流出道是否存在可能的梗阻性 ABSH。同期心肌切除术是一种安全有效的方法,没有额外的并发症,对于术前或术中诊断为 ABSH 的患者,即使没有发现动态梗阻,也应考虑进行该手术。