牙周再生的未来方法：基因治疗、干细胞和RNA干扰。

Future approaches in periodontal regeneration: gene therapy, stem cells, and RNA interference.

作者信息

Intini Giuseppe

机构信息

Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, REB 513, Boston, MA 02115, USA.

出版信息

Dent Clin North Am. 2010 Jan;54(1):141-55. doi: 10.1016/j.cden.2009.09.002.

DOI:10.1016/j.cden.2009.09.002

PMID:20103477

Abstract

Periodontal disease is a major public health issue and the development of effective therapies to treat the disease and regenerate periodontal tissue is an important goal of today's medicine. This article highlights recent scientific advancements in gene therapy, stem cell biology, and RNA interference with the intent of identifying their potential in periodontal tissue regeneration. Results from basic research, preclinical, and clinical studies indicate that these fields of research may soon contribute to more effective regenerative therapies for periodontal disease.

摘要

牙周病是一个重大的公共卫生问题，开发有效的治疗方法来治疗该疾病并使牙周组织再生是当今医学的一个重要目标。本文重点介绍了基因治疗、干细胞生物学和RNA干扰方面的最新科学进展，旨在确定它们在牙周组织再生中的潜力。基础研究、临床前研究和临床研究的结果表明，这些研究领域可能很快会为牙周病带来更有效的再生治疗方法。