靶向肿瘤微环境的 SRC 激酶抑制作用。
Targeting the tumor microenvironment with SRC kinase inhibition.
机构信息
Genentech Inc., South San Francisco, CA, USA.
出版信息
Clin Cancer Res. 2010 Feb 1;16(3):775-7. doi: 10.1158/1078-0432.CCR-09-3081. Epub 2010 Jan 26.
Abstract
Although most cancer therapies are directed against tumor cells, an emerging area of cancer therapeutics focuses on targeting cells of the tumor microenvironment. Inhibiting the Src family kinase with dasatinib decreases tumor growth through inhibiting growth of tumor-associated endothelial and myeloid cells.
摘要
虽然大多数癌症疗法针对的是肿瘤细胞，但癌症治疗的一个新兴领域侧重于针对肿瘤微环境中的细胞。用达沙替尼抑制Src 家族激酶通过抑制肿瘤相关内皮细胞和髓样细胞的生长来减少肿瘤生长。
Zotero 插件